17 September, 2015
Next Generation Sequencing is the “digital” sequence-based alternative to analog techniques for DNA analysis. With its exceptional data and scalability, it allows us to study chromosomes at a level never before possible.
NGS provides a new approach to PGS with advantages including:
1) State-of-the-art technology:
More detailed genetic information can be obtained through the complete genome sequencing of embryos.
2) High resolution:
Possibility to detect segmental aneuploidies on embryos (deletions/duplications).
This technique can be applied using the same approach for different indications such as for translocation and, in the future, also for single gene disorders.*
3) High Accuracy rate:
PGS by NGS achieves an accuracy rate of 98%.
4) Improvement in clinical results:
Due to higher dynamic range of NGS technology, increasing the detection capability of mosaicism and segmental abnormalities.*
* Vera et al., 2015. Distribution patterns of segmental aneuploidies in human blastocysts identified by next-generation sequencing. In press