POC

Products of Conception

Studies foetal tissue from a lost pregnancy to check whether the miscarriage was the result of chromosomal aneuploidy

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Overview

  • 50% of miscarriages in the first trimester are caused by chromosomal abnormalities.
  • For women undergoing assisted reproduction treatment this proportion is 60% and increases with the woman's age.
  • All 24 chromosomes are analysed to identify the reason for the pregnancy failure.
  • The mother's blood is taken to rule out any contamination in the foetal sample.
  • Information from the POC test can help patients choose future reproductive options to ensure a healthy pregnancy.
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Benefits

  • Results are obtained in >98% of cases.
  • Results are available quickly as cell culture is not required.
  • False negative results caused by maternal contamination can be ruled out.
  • STR microsatellite (DNA fingerprinting) technology is used to identify the maternal or foetal origin of the material analysed.
  • NGS has higher resolution than a conventional karyotype.
  • Can be performed on twin pregnancies.

Indications

The POC test is suitable for:

  • Women who have suffered a pregnancy loss.
  • Women who have experienced recurrent miscarriages.
  • Couples undergoing assisted reproduction treatment, as useful information to guide future treatment choices.
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Methodology

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Relevant data

25%

50%

60%

100%

Of all recognised pregnancies are miscarriages

Of first trimester pregnancy losses are due to chromosomal abnormalities

Of first trimester pregnancy losses are due to chromosomal abnormalities after assisted reproduction treatments

Analysis of all 24 chromosomes

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