Selecting normal embryos can increase the pregnancy chances after transfer.
In the general population, 25% of all clinical pregnancies
end in miscarriage.
Some pregnancies with chromosomal anomalies can give rise to the birth of baby with a serious illness.
According to internal data and several independent clinical studies, selecting normal embryos might increase the pregnancy possibilities after transfer.
In the general population, 25% of all clinical pregnancies end in miscarriage and almost half are chromosomally abnormal.
Therefore, especially in high-risk groups, the PGS reduces the risk of misscarriage.
The PGS increases the possibility of having a healthy baby, as it allows chromosomally normal embryos to be identified.
The mean theoretical time to achieve a LB (weeks) decreases from 14.9 to 7.7 weeks with PGS (1)
PGS helps to avoid repeating cycles of assisted reproduction and can help to reduce the number of multiple pregnancies performing by supporting single embryo transfer
We use the most advanced technology, NGS (Next-Generation Sequencing) to perform the PGS test:
Our technology and experience allows to analyse 24 chromosomes, in a 12-hour procedure which provides results in more than 99% of cases.
Twin pregnancy is associated with more pregnancy complications and poorer pregnancy outcome than singleton pregnancy.
The development of the IVF techniques and recent studies* demonstrate:
*Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. (Sills ES, Salem RD. 1. Mol Cytogenet. 2012 May 2;5(1):24.)More info
Multiple pregnancy has increased risks for the mother and the babies:
Scientific publications and documents.
PGS Specialists Brochure
1: Rubio et al: In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Fertil Steril. 2017 May;107(5):1122-1129.
2: Rubio et al: Preimplantation genetic screening using fluorescence in situ hybridization inpatients with repetitive implantation failure and advanced maternal age: two randomized trials.
Fertil Steril. 2013 Apr;99(5):1400-7.
3. Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study.
Mol Cytogenet 2012 May 2; 5(1):24.
4. Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, Ata B, Cohen J, Munné S. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial.
Fertil Steril. 2017 Mar;107(3):723-730.e3.
5. Coates A, Bankowski BJ, Kung A, Griffin DK, Munne S. Differences in pregnancy outcomes in donor egg frozen embryo transfer (FET) cycles following preimplantation genetic screening (PGS): a single center retrospective study.
J Assist Reprod Genet. 2017 Jan;34(1):71-78.
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